Linda Scoriels
Ph.D, HDR
Maîtresse de conférences
Université Paris Cité
Linda est chercheuse au LaPsyDÉ et enseignante à l'Institut de Psychologie de l’Université Paris Cité. Elle a fait un Magistère de Génétique, suivi d’un Master en Neurosciences Cognitives à Paris entre 2002 et 2005. Elle a ensuite réalisé un Doctorat dans le département de Psychiatrie de l’université de Cambridge, en Angleterre, sous la direction de Peter Jones en 2011, suivi d’un premier postdoctorat. Puis, suite à l’obtention d’un financement « Jeunes talents » du gouvernement brésilien, Linda est partie à l’Université Fédérale de Rio de Janeiro (UFRJ), où elle a réalisé son second postdoctorat, suivi d’un poste de maîtresse de conférences à la Faculté de Médecine de l’UFRJ.
À son retour à Paris, en 2021, elle a rejoint l’équipe Krebs à l’Institut de Psychiatrie et Neurosciences de Paris, où elle a été nommée directrice scientifique de deux essais cliniques multicentriques en France (PSYCARE) et contribue au programme national French Minds (PEPR-PROPSY) dédié à la psychiatrie de précision. Elle a récemment co-dirigé/encadré les thèses de Valeria Lucarini (2021-2024), Delphine Yeh (2023-2025) et Morgane Hericher (2024-actuel).
Ses travaux de recherche portent sur les déterminants biologiques et environnementaux des processus cognitifs, émotionnels et de construction du soi dans le développement et les troubles psychiques. Ils visent à mieux caractériser les trajectoires de vulnérabilité et à développer des stratégies de renforcement ciblées, notamment pharmacologiques et numériques, afin d’améliorer les processus cognitifs et émotionnels ainsi que le fonctionnement et la qualité de vie des personnes.
PUBLICATIONS
Gosling, C. J., Cartigny, A., Scoriels, L., Portalier, C., Laidi, C., & Mallet, J. (2025). La flexibilité cognitive : une dimension cognitive clé. Médecine/Sciences, 41(5), 443–450. https://doi.org/10.1051/medsci/2025075 | More |
Yrondi, A., Rey, R., Scoriels, L., Godin, O., & Leboyer, M. (2025). L’Anhédonie. Médecine/Sciences, 41(5), 425–433. https://doi.org/10.1051/medsci/2025062 | More |
Lucarini, V., Grice, M., Wehrle, S., Cangemi, F., Giustozzi, F., Amorosi, S., Rasmi, F., Fascendini, N., Magnani, F., Marchesi, C., Scoriels, L., Vogeley, K., Krebs, M.-O., & Tonna, M. (2024). Language in interaction: Turn-taking patterns in conversations involving individuals with schizophrenia. Psychiatry Research, 339, 116102. https://doi.org/10.1016/j.psychres.2024.116102 | |
Woodruff, E., Poltronieri, B. C., Sousa, L. P. de A., de Oliveira, Y. G., Reis, M. A., Scoriels, L., & Panizzutti, R. (2024). Effects of bottom-up versus top-down digital cognitive training in older adults: A randomized controlled trial. Archives of Gerontology and Geriatrics, 127, 105552. https://doi.org/10.1016/j.archger.2024.105552 | |
Yeh, D., Penaud, S., Gaston-Bellegarde, A., Scoriels, L., Krebs, M.-O., & Piolino, P. (2024). Impact of minimal self disorders on naturalistic episodic memory in first-episode psychosis and parallels in healthy individuals with schizotypal traits. Frontiers in Psychiatry, 15, 1469390. https://doi.org/10.3389/fpsyt.2024.1469390 | |
Yeh, D., He, Q., Krebs, E., Iftimovici, A., Martinez, G., Bourgin-Duchesnay, J., Mouaffak, F., Danset-Alexandre, C., de Gasquet, M., Jantac, C., Bendjemaa, N., Chaumette, B., Krebs, M.-O., & Scoriels, L. (2024). Cognitive impairment in the schizophrenia spectrum: Exploring the relationships of the g-factor with sociodemography, psychopathology, neurodevelopment, and genetics. Psychological Medicine, 54(15), 1–12.https://doi.org/10.1017/S0033291724002538 | More |
Iftimovici, A., Krebs, E., Dalfin, W., Legrand, A., Scoriels, L., Martinez, G., Bendjemaa, N., Duchesnay, E., Chaumette, B., & Krebs, M.-O. (2024). Neurodevelopmental predictors of treatment response in schizophrenia and bipolar disorder. Psychological Medicine, 54(13), 1–12. https://doi.org/10.1017/S0033291724001776 | More |
Mororó, L. G., Guimarães, A. L., Costa, A. C., Genaro, L., Cavalcanti, M. T., Scoriels, L., & Panizzutti, R. (2023). Association between motivation and engagement with changes in cognition and symptoms after digital cognitive training in schizophrenia. Schizophrenia Research, 251, 1–9. https://doi.org/10.1016/j.schres.2022.12.002 | |
Pelegrino, A., Guimaraes, A. L., Sena, W., Emele, N., Scoriels, L., & Panizzutti, R. (2023). Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia. Frontiers in Psychiatry, 14, 1190329. https://doi.org/10.3389/fpsyt.2023.1190329 | |
Frajerman, A., Urban, M., Rivollier, F., Plaze, M., Chaumette, B., Krebs, M.-O., & Scoriels, L. (2023). Abnormalities in one-carbon metabolism in young patients with psychosis. Frontiers in Psychiatry, 14, 1128890. https://doi.org/10.3389/fpsyt.2023.1128890 | More |
Guimarães, A. L., Richer Araujo Coelho, D., Scoriels, L., Mambrini, J., Ribeiro do Valle Antonelli, L., Henriques, P., Teixeira-Carvalho, A., Assis Martins Filho, O., Mineo, J., Bahia-Oliveira, L., & Panizzutti, R. (2022). Effects of Toxoplasma gondii infection on cognition, symptoms, and response to digital cognitive training in schizophrenia. Schizophrenia (Heidelberg, Germany), 8(1), 104. https://doi.org/10.1038/s41537-022-00292-2 | More |
Scoriels, L., Genaro, L. T., Keffer, S., Guimarães, A. L., Barros-Dumas, B., Mororó, L. G., Biagioni, T., Lucena, C., da Hora, T. R., Sahakian, B. J., Fisher, M., Vinogradov, S., & Panizzutti, R. (2022). Changes in emotion processing and social cognition with auditory versus visual neuroscience-informed cognitive training in individuals with schizophrenia. Schizophrenia Research, 241, 267–274. https://doi.org/10.1016/j.schres.2022.02.013 | |
Couturier, A., Chaumette, B., Kebir, O., Iftimovici, A., Krebs, E., He, Q., Jiao, C., Krebs, M.-O., Scoriels, L., & Frajerman, A. (2022). The impact of BDNF on the cognitive functions of ultra-high risk patients: An exploratory study. Schizophrenia Research, S0920-9964(22)00432-7. https://doi.org/10.1016/j.schres.2022.11.016 | |
Genaro, L. T., Santos, P. V., Mororó, L. G. C., Panizzutti, R., & Scoriels, L. (2021). The psychometric properties of the Behavioral Inhibition and Activation Systems motivational scale and a Brazilian Portuguese validation. Learning and Motivation, 75, 101743. https://doi.org/10.1016/j.lmot.2021.101743 | |
Frajerman, A., Scoriels, L., Kebir, O., & Chaumette, B. (2021). Shared Biological Pathways between Antipsychotics and Omega-3 Fatty Acids: A Key Feature for Schizophrenia Preventive Treatment? International Journal of Molecular Sciences, 22(13), Article 13. https://doi.org/10.3390/ijms22136881 | More |
Toll, A., Bergé, D., Burling, K., Scoriels, L., Treen, D., Monserrat, C., Marmol, F., Duran, X., Jones, P. B., Pérez-Solà, V., Fernandez-Egea, E., & Mané, A. (2020). Cannabis use influence on peripheral brain-derived neurotrophic factor levels in antipsychotic-naïve first-episode psychosis. European Archives of Psychiatry and Clinical Neuroscience, 270(7), 851–858. https://doi.org/10.1007/s00406-020-01117-y | |
Scoriels, L., Genaro, L. T., Mororó, L. G. C., Keffer, S., Luiza, A., Guimarães, D. V., Ribeiro, P. V. S., Tannos, F. M., Novaes, C., França, A. I., Goldenstein, N., Sahakian, B. J., Cavalcanti, M. T., Fisher, M., Vinogradov, S., & Panizzutti, R. (2020). Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life. Schizophrenia Research, 222, 319-326. https://doi.org/10.1016/j.schres.2020.05.017 | More |
Scoriels, L., Zimbron, J., Garcia-León, N., Coll-Negre, M., Giro, M., Perez, J., Jones, P. B., & Fernandez-Egea, E. (2019). Cross-sectional study of diet patterns in early and chronic schizophrenia. Schizophrenia Research, 208. https://doi.org/10.1016/j.schres.2019.03.029 | |
Lennox, B. R., Pollak, T., Palmer-Cooper, E. C., Scoriels, L., Harrison, P. J., Jones, P. B., Lang, B., Crowley, H., Marks, J., & Vincent, A. (2017). Serum neuronal cell-surface antibodies in first-episode psychosis–Authors’ reply. The Lancet Psychiatry, 4(3). https://doi.org/10.1016/S2215-0366(17)30053-6 | |
Lennox, B. R., Palmer-Cooper, E. C., Pollak, T., Hainsworth, J., Marks, J., Jacobson, L., Lang, B., Fox, H., Ferry, B., Scoriels, L., Crowley, H., Jones, P. B., Harrison, P. J., & Vincent, A. (2017). Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: A case-control study. The Lancet Psychiatry, 4(1). https://doi.org/10.1016/S2215-0366(16)30375-3 | More |
Scoriels, L., Avellar, M., Madeira, C., Vargas-Lopes, C., Marques, P., Dantas, C., Manhães, A. C., Leite, H., & Panizzutti, R. (2016). The effect of D-serine administration on cognition and mood in older adults. Oncotarget, 7(11). https://doi.org/10.18632/oncotarget.7691 | More |
Calderon, J., Flores, P., Aguirre, J. M., Valdivia, G., Padilla, O., Barra, I., Scoriels, L., Herrera, S., Gonzalez, A., & Massardo, L. (2016). Impact of cognitive impairment, depression, disease activity, and disease damage on quality of life in women with systemic lupus erythematosus. Scandinavian Journal of Rheumatology, 1–8. https://doi.org/10.1080/03009742.2016.1206617 | |
Massardo, L., Bravo-Zehnder, M., Calderón, J., Flores, P., Padilla, O., Aguirre, J. M., Scoriels, L., & González, a. (2015). Anti-N-methyl-D-aspartate receptor and anti-ribosomal-P autoantibodies contribute to cognitive dysfunction in systemic lupus erythematosus. Lupus, 24(6), 558–568. https://doi.org/10.1177/0961203314555538 | |
Scoriels, L., Salek, R. M., Goodby, E., Grainger, D., Dean, a M., West, J. a, Griffin, J. L., Suckling, J., Nathan, P. J., Lennox, B. R., Murray, G. K., Bullmore, E. T., & Jones, P. B. (2015). Behavioural and molecular endophenotypes in psychotic disorders reveal heritable abnormalities in glutamatergic neurotransmission. Translational Psychiatry, 5(January), e540–e540. https://doi.org/10.1038/tp.2015.26 | More |
Xu, M. K., Gaysina, D., Barnett, J. H., Scoriels, L., van de Lagemaat, L. N., Wong, a, Richards, M., Croudace, T. J., & Jones, P. B. (2015). Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders. Translational Psychiatry, 5(6), e593–e593. https://doi.org/10.1038/tp.2015.86 | More |
Calderón, J., Flores, P., Babul, M., Aguirre, J., Slachevsky, a, Padilla, O., Scoriels, L., Henríquez, C., Cárcamo, C., Bravo-Zehnder, M., González, a, & Massardo, L. (2014). Systemic lupus erythematosus impairs memory cognitive tests not affected by depression. Lupus, 2014, 1042–1053. https://doi.org/10.1177/0961203314536247 | |
Zandi, M. S., Deakin, J. B., Morris, K., Buckley, C., Jacobson, L., Scoriels, L., Cox, A. L., Coles, A. J., Jones, P. B., Vincent, A., & Lennox, B. R. (2014). Immunotherapy for patients with acute psychosis and serum N-Methyl d-Aspartate receptor (NMDAR) antibodies: A description of a treated case series. Schizophrenia Research, 160(1–3). https://doi.org/10.1016/j.schres.2014.11.001 | |
Panizzutti, R., Scoriels, L., & Avellar, M. (2014). The co-agonist Site of NMDA-glutamate receptors: A novel therapeutic target for age-related cognitive decline. Curr Pharm Des, 20(32), 5160–5168. | |
Scoriels, L., Jones, P. B., & Sahakian, B. J. (2013). Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain. Neuropharmacology, 64, 168–184. https://doi.org/10.1016/j.neuropharm.2012.07.011 | |
Dean, a M., Goodby, E., Ooi, C., Nathan, P. J., Lennox, B. R., Scoriels, L., Shabbir, S., Suckling, J., Jones, P. B., Bullmore, E. T., & Barnes, A. (2013). Speed of facial affect intensity recognition as an endophenotype of first-episode psychosis and associated limbic-cortical grey matter systems. Psychological Medicine, 43(3), 591–602. https://doi.org/10.1017/S0033291712001341 | |
Fernandez-Egea, E., Scoriels, L., Theegala, S., Giro, M., Ozanne, S. E., Burling, K., & Jones, P. B. (2013). Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 46, 25–28. https://doi.org/10.1016/j.pnpbp.2013.06.011 | |
Scoriels, L., Barnett, J. H., Soma, P. K., Sahakian, B. J., & Jones, P. B. (2012). Effects of modafinil on cognitive functions in first episode psychosis. Psychopharmacology, 220(2), 249–258. https://doi.org/10.1007/s00213-011-2472-4 | |
Scoriels, L., Barnett, J. H., Murray, G. K., Cherukuru, S., Fielding, M., Cheng, F., Lennox, B. R., Sahakian, B. J., & Jones, P. B. (2011). Effects of modafinil on emotional processing in first episode psychosis. Biological Psychiatry, 69(5), 457–464. https://doi.org/10.1016/j.biopsych.2010.09.043 | |
Barnett, J. H., Scoriels, L., & Munaf, M. R. (2011). Reply to: With great power comes great responsibility: Meta-analytic proof for a timeless insight. Biological Psychiatry, 69(10). https://doi.org/10.1016/j.biopsych.2010.11.028 | |
Scoriels, L., Barnett, J., & Jones Peter, B. (2010). Modafinil for schizophrenia. Cochrane Database of Systematic Reviews, 9. https://doi.org/10.1002/14651858.CD008661 | |
Kirkbride, J. B., & Scoriels, L. (2009). Review of the 6th symposium for the search for the causes of schizophrenia, Sao Paulo, Brazil, 3-6 February 2009. European Archives of Psychiatry and Clinical Neuroscience, 259(8), 505–509. https://doi.org/10.1007/s00406-009-0025-1 | |
Barnett, J. H., Scoriels, L., & Munafò, M. R. (2008). Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism. Biological Psychiatry, 64(2), 137–144. https://doi.org/10.1016/j.biopsych.2008.01.005 | |
Mechawar, N., Saghatelyan, A., Grailhe, R., Scoriels, L., Gheusi, G., Gabellec, M.-M., Lledo, P.-M., & Changeux, J.-P. (2004). Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb. Proceedings of the National Academy of Sciences of the United States of America, 101(26), 9822–9826. https://doi.org/10.1073/pnas.0403361101 | More |